Kidney Syndromes
Content
ephrotic Syndrome..Ὴ(NS) Nephrotic
Prepared by:Mohammad Ali Al-shehri Ὴ.. Supervised by : Dr.
Introduction
Definition of NS Etiology of NS Pathology of NS Pathophysiology of NS Clinical Manifestation of NS Complication NS Laboratory Data Diagnosis Treatment
ephrotic syndrome Nephrotic Nephrotic syndrome (NS) results from increased permeability of Glomeulrar basement membrane ( GBM ) to plasma protein. It is clinical and laboratory syndrome characterized by massive proteinuria, which lead to hypoproteinemia ( hypoalbuminemia), hyperlipidemia and pitting edema. (4-increase,
1-decrease).
Nephrotic Criteria:*Massive proteinuria: qualitative proteinuria: 3+ or 4+, quantitative proteinuria : more than mg/m2/hr in children selective).
*Hypo-proteinemia : total plasma proteins < 5.5g/dl and serum albumin : < 2.5g/dl.
*Hyperlipidemia : serum cholesterol :
* Edema : pitting
edema
>
5.7mmol/L
in different
degree
40
Nephr i tic Criteria
-Hematuria:
- Hypertension:
RBC in urine (gross hematuria)
ᶟ130/90 mmHg in in preschool-age school-age children ᶟ120/80 mmHg children ᶟ110/70 mmHg in infant and toddlerᾼs children
-Azotemia renal insufficiency ）: Increased level of serum BUN - Hypo-complementemia: Decreased level of serum c3
Cr
Prepared by:Mohammad Ali Al-shehri Ὴ.. Supervised by : Dr.
Introduction
Definition of NS Etiology of NS Pathology of NS Pathophysiology of NS Clinical Manifestation of NS Complication NS Laboratory Data Diagnosis Treatment
ephrotic syndrome Nephrotic Nephrotic syndrome (NS) results from increased permeability of Glomeulrar basement membrane ( GBM ) to plasma protein. It is clinical and laboratory syndrome characterized by massive proteinuria, which lead to hypoproteinemia ( hypoalbuminemia), hyperlipidemia and pitting edema. (4-increase,
1-decrease).
Nephrotic Criteria:*Massive proteinuria: qualitative proteinuria: 3+ or 4+, quantitative proteinuria : more than mg/m2/hr in children selective).
*Hypo-proteinemia : total plasma proteins < 5.5g/dl and serum albumin : < 2.5g/dl.
*Hyperlipidemia : serum cholesterol :
* Edema : pitting
edema
>
5.7mmol/L
in different
degree
40
Nephr i tic Criteria
-Hematuria:
- Hypertension:
RBC in urine (gross hematuria)
ᶟ130/90 mmHg in in preschool-age school-age children ᶟ120/80 mmHg children ᶟ110/70 mmHg in infant and toddlerᾼs children
-Azotemia renal insufficiency ）: Increased level of serum BUN - Hypo-complementemia: Decreased level of serum c3
Cr
